Plos.

Main Category: Also in, the immune response system may affect the risk of relapse - overactive immune response seems to increase risk, say researchers from Washington University School of Medicine in St. Louis. Their research published in medical journal

pathogens PLOS. Scientists used a model mouse to demonstrate that severe inflammatory reaction in the initial urinary tract infection (UTI) can cause damage to the bladder, leading to more robust infection. They also found that immunodeficient mice - mice with weak immune systems - that there was such severe inflammatory reactions were much less likely to suffer from chronic (long-term, recurring) infection of the urinary bladder. They also showed that mice with a history of chronic infections of the urinary bladder, which was subsequently cured with treatment develop persistent immune cell infiltration in the bladder wall, and in these mice are highly susceptible to further UTI. Lead study author Thomas J. Hannan, DVM, PhD. Said:

We found markers in mice that may one day help us identify patients vulnerable to relapse of infection and refine our strategy of treatment. There were battling the infection elements in the responses of some mice that we could, for example, be able to push through vaccines for these patients. Millions of people suffer from urinary tract infections a year. While antibiotic lasix generic treatment was effective, resistance to antibiotics is increasingly growing concern, according to Scott Halthren, Ph.D., Director, Center for Infectious Disease Research on Women, where experiments were conducted. Women and children are most at risk for having urinary tract infections, chronic and recurrent infections are common. NCI estimated to cause about $ 1. 6000000000 in medical costs annually in the United States. Researchers at the lab Halthren currently collaborating with scientists from the University of Washington and Duke University to determine whether the mouse results can lead them to markers of vulnerability to relapse of infection in humans. Thomas J. Hannan, Indira U. Mysorekar, S. Chia Hung, Megan L.

Izakson-Schmid, Scott J. Halthren

PLoS Pathog 6 (8): e1001042. DOI: 10. 1371/journal. ppat. 1001042

not be reproduced without permission of Medical >> Today News. <<